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Urol Int. Mahjoubi F, Razazian F. Constitutional complex chromosomal rearrangements in a klinefelter patient: case report and review of literature. Comparison of sperm retrieval and intracytoplasmic sperm injection outcome in patients with and without Klinefelter syndrome. Frequency of sex chromosomal disomy in spermatozoa of normal and oligozoospermic Iranian patients and its effects on fertilisation and implantation rates after ICSI. Clinical aspects of infertile 47,XYY patients: a retrospective study. Hum Fertil Camb. Male infertility in reciprocal translocation carriers: the sex body affair.

Will lead to better diagnosis and treatment

Cytogenet Genome Res. Nowroozi M. Iranian Journal of Reproductive Medicine Vol. Minimum data set for cystic fibrosis registry: a case study in iran. Acta Inform Med. Analysis of the CFTR gene in Iranian cystic fibrosis patients: identification of eight novel mutations. J Cyst Fibros. Khatami SR. A novel mutation in the transactivation-regulating domain of the androgen receptor in a patient with azoospermia. Int J Mol Cell Med. Association of sperm mitochondrial DNA deletions with male infertility in an Iranian population.

Bahrehmand Namaghi I, Vaziri H. Sperm mitochondrial DNA deletion in Iranian infertiles with asthenozoospermia. Hum Reprod. Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia. Relationship between absence of annulus and asthenozoospermia in Iranian men. Mutational screening of the NR5A1 in azoospermia. Eur J Hum Genet. Am J Hum Genet. Omrani MD. MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility.

Sensorineural deafness and male infertility:a contiguous gene deletion syndrome.

BMJ Case Rep. Ubiquitin-specific protease USP26 gene alterations associated with male infertility and recurrent pregnancy loss RPL in Iranian infertile patients. Correlation of sperm DNA damage with protamine deficiency in Iranian subfertile men. Genetic causes of male infertility.

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Salsabili N. Sadeghi-Nejad H, Farrokhi F. Genetics of azoospermia: current knowledge,clinical implications, and future directions. Part II: Y chromosome microdeletions. Ann Hum Biol.


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    Take a look at the Recent articles

    Nejati M and Karimian M. Association of androgen receptor GGN repeat length polymorphism and male infertility in Khuzestan, Iran. Association of long polyglycine tracts GGN repeats in exon 1 of the androgen receptor gene with cryptorchidism and penile hypospadias in Iranian patients. Zare-Karizi Sh. Prog Urol. Androgen receptor-CAG repeats in infertile Egyptian men. Nonlinear association between androgen receptor CAG repeat length and risk of male subfertility—a meta-analysis.

    Int J Androl ;34 4 : Iran J Basic Med Sci. The clinical significance of the POLG gene polymorphism in male infertility. J Clin Endocr Metab ; A multi-centre French study. We also recommended that couples trying to conceive stay away from harmful chemicals. This might be because of less sexual activity, lower semen volume, changes to sperm movement, a lower number of properly working sperm, or possibly lower sperm function and DNA quality.

    Male and Female Infertility Testing Panel | Centogene

    The chance of the child having some genetic or chromosomal problem also gets higher when you get older. Talking with a doctor, a sexual therapist or counsellor can often help with any negative feelings you might be having. How long have you and your partner been trying to conceive? Have you been having sex at least twice a week during this time?

    Discovery of new genetic causes of male infertility

    Do you and your partner focus sex on the fertile time of the month and how do you know when that is? Did you have undescended testicles as an infant? Have you ever had pelvic surgery or treatments for cancer? You are here Mens health.

    Acknowledgments

    Male infertility. What is male infertility?

    Understanding Male Infertility

    How common is infertility? What are the symptoms of male infertility? What causes male infertility? Sometimes, male infertility is simply genetic. What are the genetic causes of male infertility? How is infertility diagnosed? What are the treatments for infertility? Can I do anything to prevent male infertility? Can older age cause male fertility problems? The development of in vitro fertilitzation IVF has allowed many couples to have the families they might otherwise have been unable to create independently. At the same time, this technology has allowed researchers to study the genetic make-up of the earliest stages of embryos.

    These advances are providing insights into the link between genetics and infertility and how defects mutations in specific genes may result in male or female infertility. It is possible that many cases of unexplained infertility will one day be found to have a clear genetic basis. What has been learned in the last two decades of assisted reproduction is that some cases of severe male factor infertility are clearly related to gene deletions, mutations or chromosomal abnormalities.

    Some men with very severe male factor infertility will be found, upon testing their blood chromosomes known as a "karyotype" to have an extra X chromosome. This condition is known as "Klinefelter Syndrome" and can result in failure to achieve puberty or even when puberty is achieved, these men often have male infertility. So far, we are not seeing an increased risk of Klinefelter Syndrome or other chromosome abnormalities in the offspring achieved in these cases.