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During the screening of best polymer carrier for a given drug, it is important to keep in mind that it must be selected according at least three criteria. It is only when all these criteria are evaluated at the same time that a good choice will be made for the polymer carrier. The process of amorphisation by spray drying can also pose technical difficulties. Handling organic solvents, for instance, in a pharmaceutical environment is not straightforward.

The effects of moisture on pharmaceutical amorphous solid dispersion systems

It requires double skills between chemical and pharmaceutical areas. So to conclude, the development of amorphous dispersion is a quite complex technology, but all the technical difficulties can find appropriate solutions. Pharma IQ: At the 7th Annual Improving Solubility Summit, what do you expect will be the most valuable discussion points, and what do you hope to gain from being there?

S Greco: All the presentations seem to be very interesting, and will give a broad overview on this issue of low solubility. Especially I expect that the session dedicated to the very latest developments in this topic will highlight some innovative strategies and technologies of formulation and drug delivery.

Solid-State Nuclear Magnetic Resonance of Pharmaceutical Amorphous Solid Dispersion - Dimensions

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During the screening of best polymer carrier for a given drug, it is important to keep in mind that it must be selected according at least three criteria this polymer has to improve the chemical stability of the drug, so there must be a good compatibility between the drug and this polymer. Secondly, it has to improve the long-term physical stability of the drug, since the final amorphous dispersion has to be stable at least two years.

watch At last, it has also to prevent the recrystallisation of the drug in the stomach, or in the gastrointestinal tract, and this can be determined by appropriate in vitro biopharmaceutical tests. Is it a good time to be a data scientist in the pharmaceutical industry?

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    Development of Solid Dispersions at Hovione

    Amorphous Solid Dispersions Sonya Iverson T Drug candidates that are insoluble tend to have low bioavailability or limited absorption. Contact us today for a free consultation with our scientific team and discover how VxP can be a valuable resource and partner for your organization.